• br Functional consequences of ADK regulation on neuronal exc

  2024-03-14

  

  Functional consequences of ADK regulation on neuronal excitability Adenosine modulates neuronal excitability via activation of the high affinity A1 or A2A, low-affinity A2B, or low abundance A3 adenosine receptors that feed into a multitude of different neuronal and astrocytic pathways (Blum et a

• The enzyme plays an important role in the purine metabolism

  2024-03-14

  

  The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host STA9090 for its purine requirements and survival (Perrotto et al., 1971;

• br Results br Discussion Members of

  2024-03-14

  

  Results Discussion Members of the PfkB family of proteins, which exhibit AK activity, have only been found in the eukaryotic organisms in the past. Hence, the report of a PfkB family protein in MTub that exhibited AK activity was of much interest, and it necessitated closer examination of its

• Our published data showed that in mouse heart the protein

  2024-03-14

  

  Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function

• br Materials and methods br Results br

  2024-03-14

  

  Materials and methods Results Discussion Cdc42 has been implicated in mediating the entry of HCV into hepatocytes, but how Cdc42 affects the response of HCV patients to IFN therapy is unknown. This study therefore examined the genetic association between Cdc42-related genes and efficacy of

• SLIGKV-NH2 Plant material and growth conditions Arabidopsis

  2024-03-14

  

  Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark SLIGKV-NH2 in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant transformation. T

• br Acknowledgments We thank the anonymous reviewers for

  2024-03-14

  

  Acknowledgments We thank the anonymous reviewers for their constructive comments on the manuscript, and also thank Dr. Hans-U. Dahms for his comments on the manuscript. This work was supported by a grant from the National Research Foundation (2009-0071218) funded to Young-Mi Lee. This work was al

• Furthermore our lab previously reported that cadmium

  2024-03-14

  

  Furthermore, our lab previously reported that cadmium treatment increased AChE-S and decreased AChE-R variants gene expression, which mediates the cell death observed on basal forebrain cholinergic neurons (Del Pino et al., 2016b). AChE-R decreased expression, which presents a neuroprotective role i

• Finally we show that the

  2024-03-14

  

  Finally, we show that the optimal corporate tax rate is strictly positive, balancing the increase in tax revenues against the loss in consumer surplus due to higher prices and fewer firms (products). This result is related to the well-known “excessive entry theorem” that shows, for a large class of

• We found that several anticancer drugs inhibit HT receptor

  2024-03-14

  

  We found that several anticancer drugs inhibit 5-HT3 PD173955 current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used frequentl

• Introduction hydroxytryptamine HT is found throughout the bo

  2024-03-14

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary mk 801 (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current classification

• br The complementary role of chaperone mediated autophagy

  2024-03-14

  

  The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa

• Cy7 NHS ester (non-sulfonated) Introduction An association o

  2024-03-13

  

  Introduction An association of elevated branched-chain Cy7 NHS ester (non-sulfonated) (BCAA—Leu, Val, Ile) with obesity and insulin resistance was first reported nearly 50 years ago (Felig et al., 1969). With the advent of metabolomics technologies, it has since become apparent that the association

• exemplifies three of the compounds investigated

  2024-03-13

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC Cy7.5 NHS ester (non-sulfonated) as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or d

• As the effects of baclofen

  2024-03-13

  

  As the effects of baclofen on primary afferent activity are not reproduced by GABAA receptor agonists like muscimol and isoguvacine, this ionotropic receptor may play minimal role in the modulation of primary afferent activity. However, it is important to note that post-synaptic GABAA receptors rema

15547 records 186/1037 page Previous Next First page 上5页 186187188189190 下5页 Last page