• In the last decade the zebrafish has emerged as

  2024-03-11

  

  In the last decade, the zebrafish has emerged as a valuable vertebrate model to systematically dissect the genetic underpinnings of both vertebrate heart development and function [8,9], as well as distinct cardiac diseases such as congenital heart disease [10], cardiomyopathies [11,12] and cardiac a

• Significant reductions in GYN cancer patient mortality and m

  2024-03-11

  

  Significant reductions in GYN cancer patient mortality and morbidity rates require treatments that proactively prevent and reverse resistance to chemotherapy and radiation. Combining chemotherapy and radiation with inhibitors of key DDR proteins targets is likely to enhance the ability of genotoxic

• br Leptin Adiponectin a permissive imbalance

  2024-03-11

  

  Leptin/Adiponectin: a permissive imbalance Leptin, a satiety hormone, is encoded by the obesity (ob) gene. It essentially functions as an energy sensor which is involved in the regulation of body weight by sending signals to the Ozagrel HCl to reduce appetite (Woods and D'Alessio, 2008). Obesity

• In this study we first determined whether AIF

  2024-03-11

  

  In this study, we first determined whether AIF in bovine LT muscle is expressed and the mitochondria released AIF-mediated apoptosis during postmortem aging. For apoptotic issues, the mitochondrial outer membrane is permeabilized, and AIF translocates to the cytosol and to the nucleus, where it indu

• It is reported that calpain plays a

  2024-03-11

  

  It is reported that calpain-2 plays a critical role in BDNF-induced signaling and memory formation, and knockdown of calpain-2, but not calpain-1, completely suppresses BDNF-induced pathway activation and protein translation (Briz et al., 2013). BDNF prevents neuronal apoptosis or death (Ferrer et a

• br Experimental procedures br Results

  2024-03-08

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector parp inhibitor of most of the sympathetic nerve fibers, and

• br Conclusion br Conflict of Interest br Author Contribution

  2024-03-08

  

  Conclusion Conflict of Interest Author Contributions Acknowledgements This work was supported by a research grant (SR/50/AS-14/2012) from the Department of Science and Technology, New Delhi, India to CMC and CSIR Senior Research Fellowship (09/013(0339)/2010-EMR-I) to SB. Introduction

• In conclusion the results of this

  2024-03-08

  

  In conclusion, the results of this investigation suggest that the involvement of PGE2 in the pathogenesis of pulpal inflammation and repair may be related to its induction of cAMP production. PGE2-induced cAMP production in dental pulp cells is mediated by binding to the EP2 receptor, activation of

• To investigate further the clinical and

  2024-03-08

  

  To investigate further the clinical and mutational spectrum associated with -related dyskinesia, we here performed a screen in a large series of patients affected with an unexplained hyperkinetic movement disorder, resulting in the identification of 2 pediatric patients presenting with a novel pheno

• As an alternative to chronic receptor blockade we

  2024-03-08

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify epigallocatechin gallate australia adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-reg

• Previously several genes such as cytokine Lyu

  2024-03-08

  

  Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell

• MafB a member of the Maf protein family is

  2024-03-08

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in GSK 0660 with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of d

• AP activation is known to upregulate

  2024-03-08

  

  AP-1 activation is known to upregulate downstream target genes including Baricitinib phosphate D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, triggered b

• GSK343 Apelin is involved in various

  2024-03-08

  

  Apelin is involved in various physiological functions, including GSK343 contraction (Ashley et al., 2005), vasodilatation (Jia et al., 2007), feeding control (Valle et al., 2008), and metabolic homeostasis (Higuchi et al., 2007, Dray et al., 2008, Attane et al., 2010). Its plasma level is elevated i

• br Other Strategies for HIF Inhibition NSC is another HIF

  2024-03-07

  

  Other Strategies for HIF-α Inhibition NSC-644221 is another HIF-α inhibitor acting at the translational level, independently of proteasomal degradation and VHL status, and is devoid of DNA damage-inducing properties [70]. NSC-644221 arrests GW9508 in G2–M through a cell type-specific Topo-2-depe

15547 records 188/1037 page Previous Next First page 上5页 186187188189190 下5页 Last page