• Foreign polypeptide antigens can be incorporated into VLPs

  2021-10-02

  

  Foreign polypeptide antigens can be incorporated into VLPs to create “chimeric” structures, either as fusions to either end of the VLP capsid (coat) protein (CP) or as additions to well-presented loops [18]. This kind of direct fusion to the coat is usually good for small peptides, however, larger

• Due to the high structural

  2021-10-02

  

  Due to the high structural similarity between GlxI and FosA, it is possible that GlxI directed evolution experiments could produce FosA enzymatic activity in a GlxI enzyme. Although the current investigation was unable to detect FosA activity by mutation of a key metal liganding residue in the activ

• br Materials and methods br Results br Discussion The redox

  2021-10-02

  

  Materials and methods Results Discussion The redox domain that spans the region between amino ceramide kinase positions 35 and 127 of the major human AP endonuclease, APE1, regulates the sequence-specific DNA binding of various transcription factors [[52], [85]]. The existent crystal struc

• br Acknowledgements This work is supported by the Cognitive

  2021-10-02

  

  Acknowledgements This work is supported by the Cognitive Sciences and Technologies Council of Iran (CSTC, Grant No. 95P31), the Iran National Science Foundation (INSF) and the Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. The authors wish to thank Dr. Ayat Kaeidi for his

• Herein we describe the development of second generation

  2021-10-02

  

  Herein, we describe the development of second generation GSM compounds aimed at improving critical physicochemical properties while maintaining the potent activity of the parent AGSM. Ligand design focused on identifying heterocyclic replacements for the hydrophobic D-ring as a means to improve ADME

• In the case of acute

  2021-10-01

  

  In the case of acute inflammation such as ischemic injury of heart, brain, lung and kidney as wells as in the case infection related injury it is now well established that the leukocytes particularly polymorphonuclear (PMNs) Azithromycin are the first responders. Under normal circumstances these le

• Clofibric Acid Factor Xa FXa has emerged as a particularly

  2021-10-01

  

  Factor Xa (FXa) has emerged as a particularly promising target for the development of effective anticoagulant drugs because FXa acts at the convergence point of the extrinsic and intrinsic coagulation pathways. It efficiently catalyzes the conversion of prothrombin to thrombin with one molecule of F

• We also intended to determine the possible mechanism underly

  2021-10-01

  

  We also intended to determine the possible mechanism underlying EZH2 upregulation in the PC. Although no recurrent mutations of EZH2 have been described in CLL [27, 28, 29], we aimed to rule out the possibility of activating mutations in the background of EZH2 overexpression. We detected no mutation

• We examined the expression of notch in the brains of

  2021-10-01

  

  We examined the expression of notch-1 in the brains of mice following morphine or oxycodone tolerance. The results showed that notch-1 levels did not change following morphine or oxycodone tolerance, with or without the treatment of IRL-1620. This indicates the possibility that morphine or oxycodone

• br Results br Discussion In this

  2021-10-01

  

  Results Discussion In this study, six new T30695 variants were synthesized with the acyclic R or S glycerol linker instead of cgrp antagonist unit at 4, 8 or 12 T residue. Based on our previous studies on TBA-GQ, this type of modification should provoke local changes in GQ conformations in th

• br Histamine H R The cloning of the

  2021-10-01

  

  Histamine H4R The cloning of the H3R (Lovenberg et al., 1999) provided a template for the search of other (±)-CPSI 1306 synthesis receptors, and resulted in the most recent discovery of histamine H4R. This concluded with six independent groups that have reported the cloning of the H4R (Leurs et a

• GSK2578215A australia br Results br Discussion Our current

  2021-10-01

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• br Methods br Transfollicular penetration

  2021-10-01

  

  Methods Transfollicular penetration of herbs and their active constituents used for hair loss treatment The transfollicular administration of pharmacologically active molecules is recognised as a significant element for therapeutic interest, mainly with regard to delivery to specific sites of

• br Introduction In the treatment of patients with AIDS and

  2021-10-01

  

  Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s

• The expression of GLUT receptors

  2021-10-01

  

  The expression of GLUT receptors throughout the body could be considered a potential source for off-target effects even for engineered glucose-conjugated nanomedicines, as there are at least 12 types of GLUT transporters in the body, including GLUT1 in erythrocytes and the blood-brain barrier, as we

15534 records 557/1036 page Previous Next First page 上5页 556557558559560 下5页 Last page