• More recently it was discovered that BChE hydrolyzes the neu

  2020-04-30

  

  More recently, it was discovered that BChE hydrolyzes the neuropeptide gut hormone, ghrelin [25], [26], [27], [28]. Nonetheless, because the enzyme reaction is very slow, those who first reported this finding were initially reluctant to attribute a real physiological role for that phenomenon. Our ow

• roscovitine receptor Propranolol initially discovered in is

  2020-04-30

  

  Propranolol, initially discovered in 1964, is first and most widely studied as a non-selective beta-blocker. Propranolol through β-adrenergic receptor blockade has reduced heart rate and blood pressure and have anti-arrhythmogenic and anti-ischemic effects, and been proposed as an effective strategy

• In this study we reported that over expressed endogenous cen

  2020-04-30

  

  In this study, we reported that over-expressed endogenous central ET-1 exerted anti-allodynic and anti-hyperalgesic effects on SNL-induced NP for the first time. Furthermore, we showed that ETA-R mRNA Lubiprostone together with the level of ET-1 was increased in the CNS up to 21days after SNL surge

• We hypothesize that both IGF

  2020-04-30

  

  We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal RG108 in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these studies because IGF-

• In rodent models the loss of estrogens through ovariectomy

  2020-04-30

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an Calcitriol receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase in

• br Sources of funding br Disclosures

  2020-04-30

  

  Sources of funding Disclosures Acknowledgments Introduction Insulin secretion from pancreatic β cells is a fundamental process to maintain blood glucose homeostasis. During glucose-stimulated insulin secretion, high glucose causes closure of ATP-sensitive K+ channels (KATP channels), sub

• The compounds listed in Table Table Table

  2020-04-30

  

  The compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5 were biologically evaluated for their inhibition of the specific binding of a radiolabeled ligand [3H]PGE2 to membrane fractions prepared from cells stably expressing each mouse prostanoid receptor. The EP1 antagonist activity of th

• It is without doubt that the

  2020-04-30

  

  It is without doubt that the vagina plays a significant role in the perception of coital stimulation leading to sexual arousal and, finally, orgasm. In response to sensory stimulation, relaxation of vaginal vascular and nonvascular smooth muscle occurs, resulting in an increase in local blood flow a

• Despite a high affinity for progesterone and a relatively hi

  2020-04-30

  

  Despite a high affinity for progesterone and a relatively high affinity for testosterone [7], the binding of progesterone and testosterone to CBG is often disregarded [1], [2], [3]. However, the concentrations of these two hormones varies considerably under both normal physiological and pathophysiol

• The molecular mechanisms regulating the differentiation

  2020-04-30

  

  The molecular mechanisms regulating the differentiation of Th1 versus Tfh BCA Protein Quantitation Kit from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation promotes mouse naive CD4+ T 

• br EBV Infection Epstein Barr

  2020-04-30

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• br Materials and methods br Results br

  2020-04-30

  

  Materials and methods Results Discussion The investigation of oxysterols is highly complex and challenging, arising not only from the large number of molecules in this family, but also due to their low abundance in biological systems compared to cholesterol and their susceptibility for auto

• More unusual modifications also regulate DUBs Recent reports

  2020-04-30

  

  More unusual modifications also regulate DUBs. Recent reports have illustrated how reactive oxygen species (ROS) can regulate DUB activity 87, 88, 89, 90. ROS can serve as potent signaling molecules by reacting with active site cysteines of tyrosine phosphatases and some cysteine peptidases to form

• Another important issue in biosensors

  2020-04-30

  

  Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase Paclitaxel for hydrolyzing sucrose into glucose, the range of personal glucometer has

• Findings from this study also indicate that

  2020-04-30

  

  Findings from this study also indicate that DAPK regulated BimEL expression during OGD as DAPK shRNA transfection inhibited OGD-induced increase of BimEL. A previous study shows that Bim is found in ER compartment in stressed Stiripentol but not in normal cells, indicating translocation of Bim durin

15589 records 835/1040 page Previous Next First page 上5页 831832833834835 下5页 Last page